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Bradford B Lowell Selected Research

Pro-Opiomelanocortin (Proopiomelanocortin)

1/2020PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding.
3/2017A molecular census of arcuate hypothalamus and median eminence cell types.
6/2015A neural basis for melanocortin-4 receptor-regulated appetite.
12/2014Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation.
10/2012Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling.
2/2012Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone.
7/2011Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons.
12/20105-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.
11/2010A serotonin and melanocortin circuit mediates D-fenfluramine anorexia.
4/2010Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.
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Bradford B Lowell Research Topics

Disease

23Obesity
12/2021 - 04/2002
21Body Weight (Weight, Body)
01/2020 - 06/2004
8Insulin Resistance
12/2021 - 07/2002
7AIDS-Related Complex (ARC)
01/2020 - 03/2014
6Hyperphagia (Overeating)
02/2016 - 04/2008
5Hypoglycemia (Reactive Hypoglycemia)
11/2021 - 05/2007
5Type 2 Diabetes Mellitus (MODY)
05/2013 - 11/2002
4Weight Gain
02/2012 - 04/2008
3Cataplexy
12/2017 - 03/2011
3Hyperinsulinism (Hyperinsulinemia)
02/2011 - 01/2005
2Type 1 Diabetes Mellitus (Autoimmune Diabetes)
11/2021 - 01/2019
2Narcolepsy
05/2017 - 03/2011
2Sleepiness
05/2017 - 03/2011
2Pain (Aches)
12/2014 - 11/2010
2Hyperglycemia
11/2008 - 12/2003
1Delayed Puberty
01/2018
1Hypersensitivity (Allergy)
06/2017
1Anxiety Disorders (Anxiety Disorder)
03/2016
1Alcoholism (Alcohol Abuse)
04/2015
1Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
06/2013
1Starvation
05/2013
1Hypertension (High Blood Pressure)
01/2013
1Glucose Intolerance
06/2011
1REM Sleep Behavior Disorder
01/2011
1Neuralgia (Stump Neuralgia)
11/2010
1Pruritus (Itching)
11/2010
1Anorexia
11/2010
1Weight Loss (Weight Reduction)
11/2010
1Thinness
04/2010
1Fever (Fevers)
09/2007
1Mitochondrial Diseases (Mitochondrial Disease)
12/2006

Drug/Important Bio-Agent (IBA)

15Pro-Opiomelanocortin (Proopiomelanocortin)IBA
01/2020 - 06/2004
14LeptinIBA
01/2019 - 06/2004
12Glucose (Dextrose)FDA LinkGeneric
01/2021 - 11/2002
8Insulin (Novolin)FDA Link
11/2021 - 07/2002
6Peptides (Polypeptides)IBA
03/2017 - 03/2014
5Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA
01/2017 - 02/2011
5Glutamic Acid (Glutamate)FDA Link
01/2017 - 05/2007
5Leptin ReceptorsIBA
12/2016 - 06/2004
4Serotonin (5 Hydroxytryptamine)IBA
12/2010 - 07/2006
3Insulin ReceptorIBA
12/2021 - 04/2010
3Glucagon (Glukagon)FDA Link
11/2021 - 05/2007
3OrexinsIBA
12/2017 - 03/2011
3Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
06/2017 - 12/2014
3Agouti-Related ProteinIBA
01/2017 - 04/2011
3gamma-Aminobutyric Acid (GABA)IBA
01/2016 - 01/2011
2Hormones (Hormone)IBA
11/2021 - 05/2007
2Deoxyglucose (2 Deoxy D glucose)IBA
11/2021 - 05/2007
2Orexin ReceptorsIBA
01/2021 - 03/2011
2Dynorphins (Dynorphin)IBA
03/2016 - 12/2014
2Cholecystokinin (Pancreozymin)IBA
01/2016 - 12/2014
2Cre recombinaseIBA
06/2015 - 03/2011
2rho-Associated KinasesIBA
10/2013 - 10/2012
2Proteins (Proteins, Gene)FDA Link
06/2013 - 08/2002
2MelanocortinsIBA
06/2013 - 11/2010
2Blood Glucose (Blood Sugar)IBA
05/2013 - 01/2005
2Nonesterified Fatty Acids (NEFA)IBA
12/2008 - 12/2004
2GhrelinIBA
09/2008 - 12/2005
2Triglycerides (Triacylglycerol)IBA
04/2008 - 12/2006
2Adenosine Triphosphate (ATP)IBA
09/2007 - 04/2002
2Uncoupling Protein 2IBA
09/2007 - 04/2002
1Arginine Vasopressin (Argipressin)IBA
11/2021
1Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA
01/2021
1prepronociceptinIBA
01/2020
1Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)IBA
01/2018
1ElementsIBA
12/2017
1LigandsIBA
12/2017
1clozapine N-oxideIBA
12/2017
1Morphine (MS Contin)FDA LinkGeneric
06/2017
1Oxytocin Receptors (Oxytocin Receptor)IBA
01/2017
1Anti-Anxiety Agents (Anxiolytics)IBA
03/2016
1Protein Isoforms (Isoforms)IBA
02/2016
1Neuropeptide YIBA
01/2016
1Tyrosine (L-Tyrosine)FDA Link
12/2014
1Hypoglycemic Agents (Hypoglycemics)IBA
12/2014
1Non-Receptor Type 11 Protein Tyrosine PhosphataseIBA
12/2014
1NeuropeptidesIBA
12/2014
1pyrrolidonyl-beta-naphthylamideIBA
12/2014
1Neurotransmitter Agents (Neurotransmitter)IBA
12/2013
1Disks Large Homolog 4 ProteinIBA
06/2013
1postsynaptic density proteinsIBA
06/2013
1Oxytocin (Pitocin)FDA LinkGeneric
01/2012
1PTEN Phosphohydrolase (PTEN Phosphatase)IBA
06/2011
1Glycine (Aminoacetic Acid)FDA LinkGeneric
01/2011
1Capsaicin (Zostrix)FDA Link
11/2010
1Histamine (Histamine Dihydrochloride)FDA Link
11/2010
1FenfluramineIBA
11/2010
1Acetyl Coenzyme A (Acetyl-CoA)IBA
04/2010
1Mitochondrial Proteins (Mitochondrial Protein)IBA
09/2007
1Prostaglandin Receptors (Prostaglandin Receptor)IBA
09/2007
1Dinoprostone (PGE2)FDA Link
09/2007
1EnzymesIBA
05/2007
1AntimetabolitesIBA
05/2007
1Melanocortin Receptors (Melanocortin Receptor)IBA
07/2006
1genipinIBA
06/2006
1Protons (Proton)IBA
06/2006
1Ghrelin ReceptorsIBA
12/2005
1Mitochondrial Uncoupling ProteinsIBA
12/2004
1Superoxides (Superoxide)IBA
12/2003

Therapy/Procedure

1Therapeutics
04/2015